Patients may define efficacy in terms that are individual, largely variable from one patient to the other, and may encompass several attributes of a drug (e.g., speed of efficacy, duration of efficacy, tolerability, ease of use, efficacy on associated symptoms, etc).
Current guidelines suggest the use of benzodiazepines as short-term concomitant therapy with recommended first-line antidepressants to speed onset of efficacy, suppression of increased anxiety associated with initiation of serotonergic therapy, and/or short-term relief for crises; long-term use of benzodiazepines is recommended for patients deemed refractory to other available therapies [ 10, 11].
Dodick D, Brandes J, Elkind A, Mathew N, Rodichok L (2005) Speed of onset, efficacy and tolerability of zolmitriptan nasal spray in the acute treatment of migraine: a randomised, double-blind, placebo-controlled study.
Any secondary biomechanical abnormality (e.g. "fixed" knee flexion) may temper the speed of recovery (efficacy study).
With all understanding of required speed and efficacy of post-mortem examination as well as of ubiquitous financial constraints that affect the number of slides which can be processed, complete sampling and tissue banking constitutes the base of good research practice and of future scientific encounters that are expected to impact on the management of epileptic patients.
Background: This preliminary study examined the effects of electrical stimulus intensity on the speed of response and efficacy of bilateral electroconvulsive therapy (ECT) in the treatment of schizophrenia.
Charlesworth BR, Dowson AJ, Purdy A, Becker WJ, Boes-Hansen S, Farkkila M (2003) Speed of onset and efficacy of zolmitriptan nasal spray in the acute treatment of migraine: a randomised, double-blind, placebo-controlled, doseranging study versus zolmitriptan tablet.
Our study emphasizes the potential of an adenoviral-based influenza vaccine platform with the benefits of speed of manufacture and efficacy of a single dose immunization.
We also considered following patients after stopping the treatment at 16 weeks, in order to assess the durability and speed of the loss of efficacy.
Consequently, as the participants in the ACTIVE trial experience more pronounced levels of cognitive decline, future studies have the potential to provide valuable insights into the efficacy of speed-of-processing interventions in enhancing older driver safety at a community level.
The mechanism by which sugammadex encapsulates rocuronium and vecuronium appears to be superior to currently used neuromuscular block reversal strategies in terms of speed, efficacy and side effects.
