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We have also removed the term "functional" throughout (except in the last sentence of the paper where it is used in a speculative context).
Events can additionally be marked with modifiers identifying the event as being, e.g. explicitly negated, or stated in a speculative context.
As yet another speculative context that bears the potential for a new candidate biomarker, we present the involvement of LDLR in brain cholesterol metabolism serving as a putative upstream controller with downstream effects on amyloid beta peptide generation.
Also as in previously introduced event corpora, we apply two binary modifiers, Negation and Speculation, marking events as explicitly negated (e.g. 'cells did not proliferate') or stated in a speculative context (e.g. 'growth might be inhibited'), respectively.
Further, events are modeled as primary objects of annotation and bound to specific statements in text (triggers), allowing events to participate in other events and facilitating further analysis such as the identification of events stated in a negated or speculative context.
Similar(55)
But for all the technical facility or speculative claims for context, the poems in Reel wouldn't work as well as they do had their arrival not been so deeply felt.
However, it remains speculative in which context these species-specific responses evolved and if it occurs in other Alexandrium species as well.
For example, biosecurity experts present at the workshop stressed that "even if the threats associated with synthetic biology are exaggerated, this does not mean they should not be investigated" and "that in a policy context, speculative thinking can be helpful to identify worst case scenarios and potential responses to these" (Jefferson et al, 2014a, pages 21 and 43).
Actual strategic vulnerabilities create a context for speculative jitters.
It is possible (but speculative) that in this context, the occurrence of severe hypoglycemia and nonuse of CGM may both be surrogate markers for difficulties with diabetes management related tasks and behaviors.
Thus, a functional role for sHA in the tumour context in vivo remains largely speculative.
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