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Regardless of whether subprime lending, rampant speculation, underlying economic decline or, most likely, a combination of the above, triggered local market meltdowns, the fact that some cities have lost over half their value gives pause, even amidst the drumbeat of bad housing news.
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Since speculations represent the gray zone of scientific knowledge, they can provide incremental support to the main hypothesis underlying the research.
Often, you design such a treatment based on your speculation about the underlying biology of the syndrome at hand.
Having said this, understanding why there is no crowding out here is interesting, and we engage in some preliminary speculation about the underlying reasons.
In addition, an analysis of the relative contributions of each of these risk factors and associated biomarkers to the development of CHF in RA patients invites speculation into the underlying pathophysiologic mechanisms leading to myocardial dysfunction.
New insights in the hormonal effects on the brain allow speculations about mechanisms underlying our observations.
The absence of significant QTLs allows some speculations about the underlying genetic architecture.
Speculation on the mechanisms underlying this co-option event might be premature.
Authors' response: We've inserted the following paragraph into the text to address these questions:"Speculation on the mechanisms underlying this co-option event might be premature.
The detailed molecular information gathered on the breakpoints does, however, allow for speculation on the mechanism underlying CCR formation in our patients.
Speculation about the mechanisms underlying these findings could include differences in environments, such as, less safe housing and neighbourhoods, and perhaps reduced use of safety measures at home and in play [ 18].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com