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Two positively charged residues Arg 106 and Lys 117 in hTIM-1, which are conserved in the TIM family, are speculated to interact with the carboxylate group of the PS or sialic carbohydrate (Fig. 3C and 3D), while, these two residues were verified to play a key role in the interaction with Ebola GP as well.
As hFc1 lacks a positively charged protein surface (Deisenhofer 1981), the selected aptamer was speculated to interact with hFc1 via nonelectrostatic forces.
Increased risk is also established for users of HRT [ 7], which has been speculated to interact with low-risk polymorphisms in the FGFR2 gene [ 8, 9].
Moreover, FER is also broadly speculated to interact with cell wall carbohydrates by virtue of its extracellular homology with the disaccharide-binding malectin (Kessler et al., 2010; Cheung and Wu, 2011; Lindner et al., 2012; Wolf and Hofte, 2014).
Zinc finger proteins have been speculated to interact with cellulose [ 42] and to be strongly expressed in response to gravitational stress during secondary cell wall synthesis [ 15, 16, 31].
Although no functional or biochemical data are yet available for MMADHC, it is currently speculated to interact with MMACHC as part of a chaperone role to present cobalamin to the cytosolic or mitochondrial pathways (Refs 20, 62).
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MAP kinases are widely speculated to directly or indirectly interact with transcription factors in the nucleus for gene regulation.
Such TN-encoding genes have been speculated to function as adapter proteins interacting with TNL proteins or with downstream signaling components [ 17].
Optineurin, known to interact with Rab8, myosin VI and transferrin receptor (TfR), was speculated to have a role in protein trafficking.
An older female might draw more fertile females, they speculate, giving her son more opportunities to interact with them.
Therefore, we speculate that the protein encoded by foscrb Y10A fails to interact with its FERM-domain containing partner(s).
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