This is speculated to be due to decreased circulating hormones, increased differentiation of the mammary cells and/or a decrease of mammary stem cells in the gland [ 7].
This has been speculated to be a cause of decreased efficacy of ASA therapy in diabetic patients [ 28].
It has been speculated that Si is able to decrease the effect of sheath blight by motivating the defence mechanisms of the crops against pathogenesis, increase the amounts of phenolic components, and increase the activities of peroxidase, chitinases, polyphenoloxidase, β-1, 3-glucanases, and phenylalanine ammonia-lyase enzymes [ 12].
It is thus tempting to speculate that decrease synthesis of bile acids in the liver contributes more importantly to decrease in intestinal intraluminal concentrations of bile acids in cirrhosis.
Thus, it is reasonable to speculate that decreased TSP-2 expression may contribute to increased MMP-2 activation and decreased cell-matrix attachment resulting in a more free environment for vascular smooth muscle cells to migrate and remodel in diabetes.
It is tempting to speculate that decreased levels of miRNAs in older individuals, similar to senescent cells, may help cells to maintain elevated protein levels at a time when translation is depressed due to advancing age, perhaps as an energy-saving or compensatory mechanism.
It is thus tempting to speculate that decreased ADAMTS1 expression seen in NFAT1-silenced tumors contributes to their apoptotic phenotype.
51 It is reasonable to speculate that decreasing BDNF expression in an epileptic brain might decrease hyperexcitability to allow for proper memory formation with epilepsy.
Although we did not assess ET-1 precursor, which would have provided a more direct evidence of increased ET-1 synthesis, there is little reason to speculate that decreased clearance occurs as a result of DE exposure.
