The removal of 7 bp is speculated to be a prerequisite for generating strain required to draw DNA in from the opposite side of the nucleosome.
EasH appears to weakly copurify with NADP+, which we speculate may be required to stabilize the enzyme, but this cofactor is lost after more than one enzyme-purification step (see Figure S18).
Since Ret loss of function primarily leads to detached terminal dendrite branches, it is tempting to speculate that Ret might be required to recruit integrins to sites of growing dendrites to promote ECM interaction.
We speculate that Hsp90α may be required to maintain and to activate these regulators and/or to disassemble the synaptonemal complex that holds homologous chromosomes together.
Although the expression pattern of NR3A is unclear in nascent GCs, it is reasonable to speculate that NMDAR may be required for spine stabilization in addition to spine formation, depending on developmentally regulated synaptic expression of NMDARs containing a specific type of subunit.
We, therefore, speculated that JMJD2B may be required for ER transcriptional activity.
In light of above findings, we speculated that multiple administrations may be required to ensure complete re-activation of tumor suppressor genes following treatment with 5-Aza-dC and perhaps other DNA methylation inhibitors.
However, we can speculate that Nek8 activity may be required to initiate some aspect of the ciliogenesis programme, whereas its degradation may be required to prevent this initiation process from being maintained indefinitely.
As CXCL14 is present not only in the hypothalamus, but also in the cortex and hippocampus, we speculate that CXCL14 may be required for the establishment of neural circuits that are closely linked with feeding behavior.
In other words, we speculate that condensin may be required at the loci only when pol II-mediated transcription is active during mitosis.
