One can speculate that the development of nails into flattened plates reflects the discontinuation of their use for digging or for defending and attacking.
Accordingly, we speculate that the development of non-caseating epithelioid cell granuloma in this patient was not caused by systemic sarcoidosis, but rather by a sarcoid-like reaction related to gallbladder cancer.
Several authors speculate that the development of lesions may depend on different factors such as the virulence of the strain, the infectious dose, the route of infection, or the age and the immunological status of the host [ 1, 6, 8, 10, 11, 27].
Given the high prevalence of AT-repeat sequences in the P. falciparum genome, it is tempting to speculate that the development of chromatin organization as a regulatory mechanism for gene expression levels has been the driving force for the evolution of the P. falciparum genome towards its high AT-content.
It is speculated that the core mechanism behind the development of PTSD is excessive consolidation of and failure to extinguish fear memory; therefore, modulating consolidation of fear memory as part of early intervention after a traumatic experience would be a potential strategy to prevent PTSD symptoms from developing later [ 17].
Therefore, we speculated that the carotenoid degradation occurred during the development of BF.
Based on the data presented here, we speculate that the differential development of Gerbera flower types, especially that of the stamen whorl, requires more complexity than development of flowers in simple inflorescences that bear uniform flowers.
Moreover, it is tempting to speculate that the massive development of numerous B. besnoiti cysts in the tissues of SA 20 led to an increased demand in nutrients and subsequently to a negative energy balance.
Given the links between SUMOylation and the TGF-β pathway [32], [33], [34], [35], [36], [37], [38], we speculated that the defects we observed in eye development might reflect disregulation of this signaling cascade.
