Accordingly, we speculated this sequence to be crucial for the contribution of UCP2/3 to mitochondrial Ca2+ uptake of intracellularly released Ca2+.
At present, based on the distributed effects of sequence differences on quantitative linker length, we speculate that sequence differences between species could affect the overall activity of the Chd1 remodeler, but this hypothesis will be challenging to address in an in vivo context.
We speculate that sequence divergence in the unstructured terminal segments results in differential recruitment of cofactors, perhaps defining the functional distinction between CTCF in somatic cells and CTCFL in the male germ line.
At the moment, it is difficult to speculate about sequence of events leading to ERK activation and SUR2A up-regulation as oxygen sensor responding to such small change to oxygen tension is yet unknown.
We speculate that sequence variation at residue 141 and potentially other positions in the receptor-binding site of filovirus glycoproteins has been shaped by selective pressure to utilize restrictive NPC1 receptors, with potential consequences for viral host range and virulence.
It is tempting to speculate that sequence variation at residue 141 and potentially other positions in the receptor-binding site of filovirus glycoproteins represents the other half of the genetic arms race, shaped by selective pressure to utilize restrictive NPC1 receptors.
One might speculate that sequencing of motor action and sequencing of speech and thought may be of the same functional origin (cf., [ 29]).
The branching structure of the tree shown in Figure 1A, together with the active site information that is also shown in that figure, leads us to further speculate that sequences from clusters 8 and 9 may be fossil sequences that are remnants of intermediate steps in the divergence of the original GRX domain towards current day GRXs of the CGFS and CPYC classes.
Second, a hereditary molecule must contain information to guide the development of a complete organism; therefore, Watson and Crick speculated that the sequence of nucleotides might represent coded information of this sort.
We speculated that this sequence might be the putative nuclear targeting signal in Tus.
