The origins of the breed are unclear, but sources speculate it originated through some combination of black Great Danes, German Shepherds, Rottweilers, Dobermans, Boxers, Bouvier des Flandres, Thuringian Shepherds, and the Standard Schnauzer.
Increased TI in cancer has been speculated to originate from a defective proofreading activity of RNA polymerases.
The pupylation machinery of nitrospirae, in fact, was speculated to originate in Acidimicrobiales by horizontal gene transfer [ 26], which seems to be supported by the recent availability of such a genome [ 27].
On the other hand, whole-body inhalation exposure to ultrafine carbon particles have suggested some deposition in the liver, which has been speculated to originate from gastro intestinal exposure and uptake from the gut (Oberdörster et al. 2002).
He speculated that they originated in Asia, moved over the Bering Strait and headed south all the way to Chile.
They were speculated to have originated during the Crusades of the 11th century.
Furthermore, in their 1987 sequel The Messianic Legacy, Lincoln, Baigent and Leigh suggested that there was a current conflict between the Priory of Sion and the Sovereign Military Order of Malta, which they speculated might have originated from an earlier rivalry between the Knights Templar and Knights Hospitaller during the Crusades.
These results showed that the B16F10 cells-specific cytotoxicities of phenolic compounds including RD, RK, and MEHQ were speculated to be originated from the increased amounts of ROS in B16F10 cells.
On the basis of these observations, the BSE-C agent already has been speculated to have originated from atypical BSE-L after conversion in an intermediate host such as a sheep.
Some have speculated that it originates with the British Emergentists of the early part of the twentieth century.
