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It has been speculated in the case of OspC that this role may be related to immune evasion, particularly the evasion of innate immunity that would normally destroy invading spirochetes before they have a chance to establish infection [44].
miR-145 and miR-143 in these instances appear to function as a tumor suppressor and similar tumor suppressor roles for these miRNA may be speculated in the case of high grade serous carcinomas and serous borderline tumors/low grade serous carcinomas.
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Local spread into the retroperitoneum from the psoas abscess and to the extrapelvic extension over the iliac wing through the weak abdominal wall lateral to the paraspinal musculature could be speculated in our case.
But he goes on to speculate that, in the case of the older-woman-younger-man scenario, this type of romance is not sanctioned by society, therefore the women in them could suffer more stress-related health problems.
Others speculate that in the case of speech generating devices, the model of spoken output leads to an increase in speech production.
We might speculate as in the case of NGAL that the substantial amount of midkine comes from kidney not from coronary artery endothelium.
We speculate that in the case of intestinal HSL deficiency less FC is pumped back out into the intestinal lumen and consequently more cholesterol can be found in the circulation 4 h post-gavaging.
Overall, it is tempting to speculate that, in the case of the citrus canker pathogens, manipulating the auxin signaling pathway via TAL effector-targeting would be an effective way to disarm host defense responses for bacterial survival and pathogenicity.
We speculate that, in the case of acute inhibition of AMPK, either by CC or molecular knockdown, there is insufficient time for a compensatory increase of protein synthesis of alpha isoforms to occur.
Since IGF-I and IGFBP-1 were found to be inversely regulated by Smo knockdown it is tempting to speculate that in the case of IGFBP-1 GLI3 may act in a repressive manner, since GLI binding sites were predicted in the promoter region of the IGFBP-1 gene (Additional file 6: Table S5).
Since sulfur-mediated hydrogen bonds are weaker than oxygen-mediated hydrogen bonds, we speculate that in the case of the (Rp -cGMPS, Rp -cGMPS the equatoreplacingyclic oxygen withesulfur would disrupt thequatorial bonding intexocyclicwith Ala309, which may be crucial foxygensing the conformational change at the PBC that leads to activation.
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