As lysine residues in proteins undergo both acetylation and ubiquitination, the data from the present study speculate the hypothesis that acetylated form of RASSF5 may not be recognized by ubiquitin ligase Itch, which leads to the stabilization of RASSF5 in tumors.
This hypothesis, speculated for years, has only recently been confirmed by multigroup collaborations working in genome-wide association studies performed in a very large series of cases and controls from different countries, in order to increase the power to detect small effects on risk.
The Bayesian brain hypothesis was initially a computational hypothesis: it was speculated that the brain might be a prediction error detection machine because the hypothesis provided an elegant algorithm for learning.
A recently published comprehensive analysis of hormone receptor immunochemistry in 450 breast cancer patients confirmed these observations in a larger cohort and speculated on a possible hypothesis for the mechanism of changes in ER and PgR status after PST (Taucher et al, 2003a).
The "jolly fat" hypothesis [ 29] was substantiated only in men by another study [ 30], in which the authors speculated that the "jolly fat" hypothesis may not apply to women because they are more likely than men to be stigmatized for being overweight or obese in industrialized societies.
That hypothesis speculates that circulation in the mantle affects circulation in the outer core, which in turn affects the inner core in something like a chain reaction.
We do not know what the nuclear function of Tollip may be but we can speculate on some hypothesis.
We speculate (as a hypothesis to be tested) that this may indicate a compensatory mechanism, whereby genes related to ASP are concomitantly increased with genes related to lipid storage, however this remains to be tested in future studies.
The current mutator hypothesis speculates that a small number of 'driver' alterations exist and, once acquired by somatic mutation, confer the cancer phenotype; however, seemingly insignificant 'passenger' mutations result via mechanisms yet to be elucidated [ 26].
Based on our observations one might speculate that our hypothesis may not only hold for the cell cycle of S. cerevisiae but also for the cell cycle of other organisms.
