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WW domains are small globular protein interaction modules found in a wide spectrum of proteins.
In Drosophila, while Neurexin (Dnrx) and Neuroligins (Dnlg) are emerging as central organizing molecules at synapses, very little is known of the spectrum of proteins that might be recruited to the Dnrx/Dnlg trans-synaptic interface for organization and growth of the synapses.
In contrast, although vertebrate CaM (VCaM) binds a spectrum of proteins similar to that for AnCaM, it is unable to fully activate CMKA and CMKB, displaying a higher K(CaM) and reduced Vmax for both enzymes.
High dosage of DNA damage usually triggers a persistent DDR engaging ATM, CHK2, and NBS1 which activates the cell cycle effectors p53/p16/RB, and leads to continuous and robust secretion of a large spectrum of proteins, dictated by a program coined as DDSP.
We have expressed a wide spectrum of proteins in retinas incubated in this way.
In induced internalization the spectrum of proteins clustered with the receptor changes and CD4 becomes associated with components of signal transduction and transport.
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A broad spectrum of protein targets capable of being modulated by them reflects the prevalence of this strategy.
The most potent compounds underwent evaluation in a broad spectrum of protein kinases, while their pharmacokinetic parameters were measured by LC-MS/MS.
Extensive in the brains of higher organisms, alternative splicing might be the primary mechanism for generating the spectrum of protein activities that support complex brain functions.
Precipitation was not seen within this broad spectrum of protein concentrations.
Amyloidosis comprises a rare spectrum of protein deposition diseases that diffusely or focally affect any organ.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com