Because of the wide spectrum of indications and the different techniques used, amniotic membrane transplantation (AMT) may result in many variants of wound healing.
All of these should promote the use of allergen immunotherapy both by increasing the number of patients and by extending spectrum of indications of immunotherapy beyond allergic respiratory diseases.
Mephenytoin (3-methyl-5-ethyl-5-phenylhydantoin, Mesantoin®) has the same spectrum of indications as phenytoin, but its use is limited to the cases unable to tolerate other drugs [2].
However, thanks to recent investigations, RDW measurements are requested for a wider spectrum of indications [ 8].
Local drug administration has been used as a therapeutic modality for many years and for a broad spectrum of indications.
This situation gets more dramatic by expanding the spectrum of indications on the basis of dubious diagnoses with the aid of technical equipment such as kirlian photograpy.
This along with the fact that data about the efficacy of neoadjuvant AD changed during years (Pilepich et al, 1995; Laverdiere et al, 1997), resulted in a wide spectrum of indications and duration of neoadjuvant AD.
3, 4 Newer chemotherapy agents such as the epothilones are a novel class of MTSA with demonstrated antitumor activity in a broad spectrum of indications including in taxane-resistant tumors.
The report by Inman et al. [ 1] on eculizumab-induced reversal of dialysis-dependent kidney failure from C3 glomerulonephritis illustrates some of the complexities associated with the prescription of eculizumab, including the expanding spectrum of indications and the timing of administration.
If we consider only patients treated with patupilone doses of 8.0 mg m 2 and higher that are thought to represent an active dose range and have been used across the spectrum of indications in phase II or III trial setting, the response rate may be even higher (4 out of 21 patients; 19%).
This can partially be due to decrease in prices, but also the use of quetiapine for a spectrum of new indications, for example for sleep disorders, can explain the phenomenon.
