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Our future work will address the relationship between sample size and the ability of linear regression to detect cell-type-specific differentially expressed genes across the whole spectrum of gene expression levels.
These observations were unexpected given that the four deleted genes span a vast spatio-temporal spectrum of gene expression (Figures 2B and S1).
The present genome-wide microarray study of implant ossoeintegation suggests that the specific microenvironment induced by implant placement significantly affect a spectrum of gene expression networks, possibly including peripheral circadian rhythm mechanisms.
The patterns of gene induction for intracellular and parental strains were similar, whereas the secretion strain had a broader spectrum of gene expression level changes.
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An additional hierarchical cluster analysis identified broad spectra of gene expression patterns during seed development.
In lung, both mouse models showed similar spectra of gene expression patterns for these functional groups, except genes for immune response and macrophage activation that were more highly altered in 9 V/null mice.
In particular, the reanalysis by Alter et al. [ 5] was one of the first to illustrate that the spectra of gene expression data can represent important biological features, in this case phases of the yeast cell cycle.
We included a broad spectrum of gene-expression studies, including ones that are (1) cross-sectional or longitudinal design, (2) on different microarray platforms, (3) on whole blood or purified leukocytes, (4) in healthy volunteers or infected human hosts, and (5) paediatric or adult patients.
Emerging evidence points to two-way interactions between DNA damage and epigenetic changes that collectively determine the spectrum of genomic rearrangements and profiles of gene expression in tumors.
This is in contrast to studies using bulk tumor DNA, RNA or protein for analysis of gene expression patterns, mutation spectra, copy number changes, et cetera.
Target specificity and kinetic properties of HDACIs probably define the spectrum of genes whose expression they affect, explaining why a catastrophic general deregulation of gene expression is not observed with their use.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com