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The spectrum of endpoints displaying hormetic dose responses is also broad being inclusive of growth, longevity, numerous metabolic parameters, disease incidences (including cancer), various performance endpoints such as cognitive functions, immune responses among others.
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Studies assessing the influence of vegetable and fruit consumption on bone health and osteoporosis cover a broad spectrum of topics, since different endpoints are considered.
Several aspects of developmental toxicity can already be examined using standardized protocols, and others must be added to cover the full spectrum of organ functions and disease endpoints that may be affected.
Furthermore, pharmacological inhibition of inflammatory reactivity is demonstrated by a broad spectrum of drugs with a common endpoint in conferring neuroprotection in peptide-injected animals.
Whereas it is clear that AChE inhibition is not the most sensitive endpoint, the spectrum of effects reported in vitro, in animal models and in humans coherently supports that endocrine effects, especially in susceptible time windows, should deserve more attention in the risk assessment of OP insecticides for a twofold reason.
These are, of course, just the endpoints of the spectrum of scientific motivations for change in nuclear medical physics, and most advances will be influenced to a greater or lesser extent by both.
These applications exhibit the two endpoints of the spectrum of phage surface display control.
Although the responses as measured by a spectrum of cell proliferation and cell signaling endpoints showed some heterogeneity, a number of definitive conclusions were drawn.
Beta particles from 131I main beta spectrum with endpoint energy of 606 keV (89.4% yield) and maximum range of 2.3 mm in tissue [41] result in low average LET (approximately 0.2 keV/μm).
Through analyzing renal endpoint, we extend the spectrum of potential prognostic influence of functional status to involve AKI among geriatric patients.
First of all, practice-relevant endpoints that cover a broad spectrum of AD symptoms and enable global clinical evaluation of the disease progression should be selected and included in an appropriate test-frame applicable to all disease severity stages.
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