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No description of the spectrum of defects resulting from a single point mutation of this gene exists in the ophthalmology literature.
We found that treating zebrafish embryos with RA at a low concentration (10−9 M) and 100 mM ethanol during gastrulation and somitogenesis stages significantly rescued a spectrum of defects produced by treating embryos with 100 mM ethanol alone.
The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect.
Our findings indicate that Drosophila can serve as a useful model for identifying how graded changes in signaling can produce a spectrum of defects in neural development.
While the cues guiding these neurons are not well understood, the spectrum of defects observed both before and after they cross the midline suggest that these neurons are responding to more then just midline repulsion.
This is consistent with the hypothesis that many Notch-Delta factors, including Notch, Delta, Serrate and Jagged, require proper protein fucosylation and compromised fucosylation of these proteins may account for the wider spectrum of defects seen in srn.
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Fig. 4 ESR spectra of defects for initial (1), annealed in hydrogen (2), γ-irradiated and thermally treated in hydrogen (3) nc-Si/SiO2 structures.
The two P-insertion alleles of sumo exhibited overlapping spectra of defects, with the average severity of the defects being greater in the sumok01211 GLC embryos (Table 4).
However, the spectrums of defects seen in VCI and AD overlap substantially.
To determine the birth prevalence of congenital heart defects (CHDs) across the spectrum of common defects in very/extremely premature infants and to compare mortality rates between premature infants with and without CHDs.
OBJECTIVE To determine the birth prevalence of congenital heart defects (CHDs) across the spectrum of common defects in very/extremely premature infants and to compare mortality rates between premature infants with and without CHDs.
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