EXOSC3 forms an essential part of the human RNA exosome complex, the major cellular machinery for processing, surveillance and turnover of a diverse spectrum of coding and non-coding RNA species (Jensen, 2010).
Our group recently investigated the full spectrum of coding mutations in a zebrafish cancer through exome sequencing of melanomas derived from BRAF and NRAS-driven transgenic lines [ 76].
The characteristic spectra of coding regions for the apolipoproteins Apo E of house mouse Mus musculus, Apo A-I of gilt-head sea bream Sparus aurata and Apo A-IV of chicken G. gallus are shown in Fig. 2a c.
A previous study that evaluated ICD-9-CM codes in hospital discharge data for use in obstetric research reported high positive predictive values (96%) and moderate sensitivity (64%) for the full spectrum of diabetes codes (24).
Figure 8 a Walsh codes of length 8, b corresponding spectra, c spectrally balanced codes, d spectra of balanced codes, for K = 1. Figure 9 a Walsh codes of length 8, b corresponding spectra, c spectrally balanced codes, d spectra of balanced codes, for K = 8. Figure 10 a Walsh codes of length 32, b corresponding spectra, c spectrally balanced codes, d spectra of balanced codes.
where is the free distance of the convolutional code, is the truncating order, is the weight spectrum of the code and is the pairwise error probability, defined as the probability that the decoder erroneously selects a code sequence other than the transmitted one.
As from (1), the computation of CER UB requires the knowledge of the complete weight spectrum of the code.
However, in order to compute the union bound (and its dominant term, in particular, which is known as the error floor term), we need the knowledge of the weight spectrum of the code (or, at least, of its minimum distance and the corresponding multiplicity).
If 3-regularity exists in the characteristic spectrum of a coding region, then revealing latent profility (different from 3-profility) in the spectrum determines the second level of the encoding organization.
It is known that the symbolic autocorrelation spectrum of protein coding DNA regions typically has a peak at k= N/3 frequency (Afreixo et al., 2004b; Voss, 1992; Wang and Johnson, 2002).
