Exact(8)
The non-polar fractions of M. procumbens had the largest broad spectrum activities as they were active against all the microorganisms investigated with good MIC value (MIC = 39 μg/ml).
They displayed wide spectrum activities including anticancer [7 12], antiviral [13 19] and antimicrobial activities [20 25].
Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum activities including anticancer, antiviral as well as antimicrobial activities.
The resultant triazole containing molecules show modest, but broad spectrum activities against drug sensitive and resistant Gram-negative and Gram-positive bacteria, with no observable cytotoxicity.
Broad spectrum activities, a unique mode of actions and rare resistant variants make antimicrobial peptide (AMP) a potential alternative to antibiotics.
Micronized CAP was shown to act in vitro [ 7, 10- 14, 47- 49] and in some animal model systems [ 8, 9] as a compound with broad spectrum activities.
Similar(52)
Especially, compound 17b displayed broad spectrum activity with IC50 values ranging from 0.249 μM to 0.684 μM.
JX-594 replication, transgene expression, and cytopathic effects were highly cancer-selective, and broad spectrum activity was demonstrated.
Compounds 7b, 9a, 10c and 11c showed significant strong nematicidal broad spectrum activity against all tested nematodes.
However, the approach described previously requires knowledge of the primary (licensed) user spectrum activity in order to avoid causing interference.
This finding highlights the potential broad spectrum activity of DAS181 against current and future IFV strains.
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