Noting the wide spectrum of potencies of different cofactors at saturation, Pcof, we propose a simple model in which cofactors bound in the ATP pocket shift an equilibrium between an inactive and an active conformation of Ire1.
Remarkably, 1,2,4-triazoles were found to possess a good spectrum of antifungal potency, which eventually suggested the azole template as an essential pharmacophore to diversify the biological occupations of the attendant molecules.
A similar, worldwide program the "Zyvox Annual Appraisal of Potency and Spectrum Study", or ZAAPS has been conducted since 2002., overall resistance to linezolid in 23 countries was less than 0.2%, and nonexistent among streptococci.
Enhancing the cationicity of the feleucin template may result in parallel enhancement of potency and spectrum of action.
Constant efforts made by the scientific community in collaboration with industry and academia have resulted in the improvement of penicillins and cephalosporins in terms of potency, breadth of spectrum, activity against resistant pathogens, stability, and pharmacokinetic properties.
Understanding the biotransformation of arsenic is essential to a complete understanding of human arsenicism a point that is underscored by the wealth of arsenic toxicology literature suggesting that the various chemical forms of arsenic in the human biotransformation scheme can have markedly different toxic potencies and spectra of biologic targets (Mass et al. 2001; Styblo et al. 2000, 2002).
Both were successful; many patients experienced a return of potency.
The gun is an almost laughably clear symbol of potency.
Fluoroquinolones have been the most successful antibacterial agents targeted to gyrase, but these compounds have been extensively explored both in terms of improving spectrum and potency, and overcoming bacterial resistance, and we may have reached the limits of what these compounds can provide.
Spectra of the subsequent dilutions checked the effectiveness of the 100 × dilution steps, i.e. verified that a) the lower dilutions (from pharmaceutical factory and prepared in the laboratory) were comparable and b) the provided higher potencies were effectively diluted.
