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Knowledge on the mechanism of action of these antimicrobial peptides provides information that assists in the design of antimicrobials with higher efficacy and broader spectra of action, but also on the design of peptides with higher specificity if required.
Unfortunately, due to their large spectra of action, these inhibitors are also associated with toxicity to the heart [ 64, 65].
It is interesting to note that the allelopathic compounds show spectra of action specific to determined groups of organisms allowing the modulation of their effects and action [ 89].
The studied extracts showed large spectra of action, those from L. sativa, S. edule, C. pepo and S. nigrum being active on all the 29 bacterial strains tested meanwhile those from Amaranthus hybridus, Vernonia hymenolepsis, Lactuca.carpensis and Manihot esculenta were active on 96.55% of the strains used.
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PDT has a broad spectrum of action and low mutagenic potential.
Numerous antimicrobial agents with distinct spectrums of action, pharmacokinetics, and pharmacodynamics have been used in its treatment.
Because of their broad spectrum of action, carbapenems are the standard treatment, especially in cases of nosocomial infections.
As pathogen populations are quite complex, it is important to have an evaluation of the spectrum of action of the tested genes.
The evaluation of the bacteriostatic and bactericide effect confirmed the broadest spectrum of action to be that of the mandarin essential oil.
The spectrum of action of these agents and the precise role of the endocannabinoid system (ECS) on oncogenic processes remain elusive.
Selective 18 kDa translocator protein (TSPO) ligands are expected to be therapeutic agents with a wide spectrum of action on psychiatric disorders and fewer side effects.
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