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To increase the stringency of assay evaluations, specimens with substantial numbers of polymorphisms in primer binding sites were included.
In Bangkok, the GenoType® MTBDR plus detected INH resistance, RIF resistance, and MDR-TB with a high sensitivity and 100% specificity in both isolates and AFB-positive sputum specimens, with substantial reductions in turn-around time compared with MGIT AST.
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Six of those women had DL specimens classified by cytology as atypical with substantial changes, or as malignant.
Similarly, IHC analysis of BC specimens with different stages demonstrated a substantial increase in the proportion of patients as stage advanced from stages I to III IV for both IL-4R α values of 2+ and 3+.
Yet the mix comes with substantial downsides.
"It's a single large developer, with substantial deep pockets, with a very specific agenda that doesn't necessarily align with the interests of the state," said Doug Baker, the chief executive officer of Kryosphere, a Research Triangle company that stores biological specimens.
"We're a strong company with substantial profit and substantial cash flow," he said.
"Scotland can emerge victorious with substantial gains.
Impacts are, however, associated with substantial uncertainties.
The few cases with substantial disagreement in copy number profile seem to stem from disagreement in the ploidy and were more common in specimens with low cellularity.
Both are associated with substantial toxicity [ 12].
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