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Research into the evolution of organ systems that are mainly comprised of soft parts is often stymied by the fact they are not easily preserved in the fossil record although recent close examination of specimens with advanced imaging and microscopy techniques shows these structures may be preserved more often than previously though.
Increased expression of TX synthase was found in prostate cancer specimens with advanced stage and perineural invasion [ 101].
Similarly, the clinical specimens with advanced tumor grade and clinical stage showed significantly higher levels of IL-4R α compared to low-grade/stage disease.
In an early study, we have shown increased S100A4 expression in thyroid carcinoma specimens with advanced disease stage and indicated that it may be a useful prognostic marker for thyroid carcinoma (Zou et al, 2004).
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We observed that mRNA expression for IL-4R α was significantly higher in all tumor specimens especially those with advanced clinical stage disease compared to 12 normal/noncancerous bladder specimens (Fig 3A and B).
The aim of this study was to determine the prognostic value of expression of ATP binding cassette (ABC) transporter proteins and DNA repair gene proteins by immunohistochemically staining tumor biopsy specimens from patients with advanced non-small-cell lung cancer (NSCLC) being treated with platinum-based chemotherapy.
To address the question whether BCAR4 is associated with clinical tamoxifen resistance, we studied 280 ER α-positive primary breast cancer specimens from patients with advanced disease.
Digital polymerase chain reaction-based technologies using specimens from patients with advanced disease detected circulating tumour DNA in >75% of cases (67).
Rojo F, J Tabernero, J Albanell, E Van Cutsem, A Ohtsu, T Doi, W Koizumi, K Shirao, H Takiuchi, S Ramon y Cajal, J Baselga (2006) Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma.
Immunohistochemistry was used to analyze CXCL12 expression in the reproductive tracts, including the ovaries and fallopian tubes, of healthy women, in benign and borderline epithelial tumors, and in a series of 183 tumor specimens from patients with advanced primary EOC enrolled in a multicenter prospective clinical trial of paclitaxel/carboplatin/gemcitabine-based chemotherapy (GINECO study).
Immunohistochemical staining with anti-p-Smad2 was performed on paraffin-embedded specimens from 135 patients with advanced gastric adenocarcinomas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com