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There was increased expression of matrix metalloproteinase (MMP -2 in the teMMP -2 artery as well as aortin thesue, whereas MMP-9 was found only in temporal artery specimens with astive inflammation [ 6].
Specimens with active ERK MAP kinase signalling were more frequently seen in tumours with metastases and median survival was significantly worse, 10 months compared with 27 months in samples with lower ERK MAP kinase signalling activity P-value=0.050 P-value=0.050own).
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NF- κB activation is seen in mucosal biopsy specimens from patients with active Crohn's disease and ulcerative colitis.
To overcome the heterogeneity of cell types in tissues, a methylation-wide profiling study of whole rectal biopsy specimens from patients with active and quiescent UC and CD was validated using isolated epithelial cells from rectal biopsy specimens.
In sigmoid biopsy specimens from patients with active UC, levels of 8 miRs were significantly increased and 3 were decreased compared with samples from patients without UC.
The presence of marked overproduction of type 1 interferon-inducible transcripts in blood specimens from patients with active DM and PM has potential for diagnostic use [ 19].
In the first in vivo model of GPA, Kesel et al. subcutaneously coimplanted the biopsy specimens from patients with active GPA or sinusitis (controls) with healthy allogeneic human nasal cartilage into immunodeficient mice [ 70].
(A) Colonic tissue specimens from CD patients with active disease feature a large amount of collagen fibers indicative for fibrosis as visualized by van-Gieson staining.
After obtaining IRB approved informed consent form, specimens were collected from patients with active PsA, RA and OA.
IP-10 has been shown to be involved in the response to TB, as shown by the presence of IP-10-positive cells in the bronchoalveolar lavage [ 8] or lymph node aspirate specimens with granulomas in patients with active TB [ 9].
IL-33 expression was found upregulated within the inflamed mucosa of resection specimens collected from IBD patients with active disease when compared with the expression in non-involved patient biopsies or in colon tissue from non-IBD controls (figure 1A and online supplementary tables S1 and S2).
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