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If cytological specimens such as bronchial wash specimens could replace lung biopsy specimens when analyzing EGFR mutation status in patients with inoperable lung cancer, it would be a powerful option, as repeated lung biopsy could be avoided in patients with poor clinical condition.
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Furthermore, in a study evaluating 87 resected HCC tumors, Notch1 protein (cytoplasmic) was upregulated in 89% of tumor specimens, when analyzed using immunohistochemical staining and western blot [ 40].
These values represented a statistically-significant higher level of S100A4 mRNA in the liver metastases than in the primary cancer specimens when analyzed either as two groups (P<0.001, two-tailed Mann–Whitney U-Test) or as matched pairs (P<0.015, Wilcoxon Signed Rank Pairs test).
This is because color has very little diagnostic value when analyzing specimen stained using the Pap-stain.
These findings reinforce that nucleic extractions are not necessary when analyzing clinical specimens for the presence of HSV DNA by PCR.
However, sequencing sensitivity is low (around 15-20% mutation load) and this may lead to false negative results when analyzing tumor specimens with insufficient neoplastic cells in a background of normal cells.
To understand why cor(K C) is often positive in gene-based networks but negative in sample networks, consider that in most microarray studies, and in particular when analyzing similar biological specimens, samples are highly correlated with one another (e.g. r > 0.95 when measured across all genes).
EFTEM is advantageous when analyzing a number of specimens in a short time.
Quantifying the injurious effects of lead is also difficult because of the diagnostic limitations that exist when analyzing human blood and urine specimens for lead toxicity.
When analyzing the topography of the metal specimens which were in contact with the organic molecules, it is understandable that the roughness parameters lie between the parameters of bare and blank specimens.
An increase in minimum inhibitory concentrations (MIC) for several antibiotics, including ciprofloxacin, was found when analyzing results over the time span of specimen collections.
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CEO of Professional Science Editing for Scientists @ prosciediting.com