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The tubular MT score of the individual biopsy specimens was defined as the median score obtained according to this scoring system per visual field at 40× magnification.
VEGF staining on biopsy specimens was defined as positive in 11 out of 16 cases (68,75%): 6 of these (54,5%) showed moderate VEGF staining, while the remaining 5 (45,5%) were strongly VEGF-positive.
When both a BCS specimen margin was defined as a "positive" margin or as a "close" margin and one or more of the standardized re-resection margin specimens was defined as "positive", the spatial location of these findings were evaluated to assess concordance versus disconcordance of these findings.
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Twenty-one specimens were defined to investigate the influence of these parameters.
To do this, specimens were defined that have a sufficiently long (150 mm) and straight seam line.
However, the architecture of these specimens is defined in a three-dimensional (3D) coordinate space, in volumetric terms, making the direct microscope output somehow "short" in terms of dimensionality.
The characteristics of the specimens were defined and tested by fixing the consistency at a good workability and then studying the mechanical properties, Shore C hardness and adherence to ceramic materials after both 7 and 28 days.
The characteristics of the tests specimens were defined and tested by fixing the consistency at a good workability and then determining the mechanical properties, Shore C hardness and the water vapour permeability that correlates with the pore structure obtained with Mercury Intrusion Porosimetry (MIP).
To select the HR group in the 2-year prediction model, only P 0-2) specimens were defined as progressors for LDA, while all other specimens were defined as nonprogressors.
To select the LR group in the 4-year prediction model, both P 0-2) and P 2-4) specimens were defined as progressors for LDA, while other specimens were defined as nonprogressors.
For the 2-year prediction model, only P 0-2) specimens were defined as positive for progression, while others were classified as progression-negative for LDA.
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