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In consequence, orthopedic surgeons prefer non-bone to bone specimens to guide antimicrobial therapy in many instances of suspected COM, particularly after complicated reconstructive bone surgery.
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Our group has recently developed a tumor genotyping assay to test tumor specimens prospectively and to guide clinical decision making toward targeted therapies [15].
Therefore, definitive bacteriologic diagnosis based on blood or tissue specimen cultures is necessary to guide antimicrobial treatment.
Nevertheless, the use of invasive techniques such as fibreoptic bronchoscopy, together with quantitative cultures of bronchoscopic samples obtained with bronchoalveolar lavage or protected specimen brush, can help to guide the choice of antibiotic therapy and confirm the diagnosis of VAP.
This study aimed to probe the utility of panel sequencing in identifying single nucleotide changes in routinely processed gastric resection specimens, which could be used to guide targeted therapies.
A hematoxylin and eosin-stained tissue section was prepared for each tissue specimen for pathologic review and to guide microdissection.
Recommendations are provided to guide researchers with archived specimens, as well as those preparing to launch new data collections.
Cultures from deep intraoperative specimens are used to diagnose PJI and to guide antibiotic treatment.
Numerical simulation was performed to guide the selection of specimen dimensions and to reveal the stress concentration phenomenon.
It uses a stained section to guide the dissection of the unstained adjacent specimen [ 23].
Paired serum specimens can provide rigorous diagnosis, but patients and clinicians need rapid diagnosis to guide clinical management.
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