Association of positive EGFR immunostaining, as determined by immunohistochemistry (IHC) in NSCLC specimens, with patient sensitivity to EGFR TKI treatment has been studied extensively with both positive (Cappuzzo et al, 2005; Hirsch et al, 2007) and negative (Parra et al, 2004) results reported.
Cytologic testing showed high-grade squamous intraepithelial lesions in 4 of 21 specimens (sensitivity, 19%).
With smear-negative specimens, sensitivity was 56.3% (9/16), with smear positive ones 100% (43/43) (Table 2).
We computed standard validation measures: the proportion of antibody HCV seropositive specimens, sensitivity, specificity, positive likelihood and negative likelihood ratio and the area "under the receiver operating characteristic curve (AUC) as discrimination statistics.
Also, carbon fiber reinforced and glass fiber reinforced specimens showed differences in sensitivity to strain rate and failure mechanisms, the latter of which is further confirmed by in-situ SEM tensile tests.
In addition, combining the results of direct and concentrated smears of a single specimen had a similar sensitivity to performing direct smear microscopy on two consecutive (randomly-timed and early-morning) sputum specimens (64% vs. 63%, difference 1%, 95% confidence interval: [-6%, 8%], p = 0.85).
Both CAFs from breast and lung cancer specimens showed a significantly lower sensitivity to paclitaxel than the tumor cell line panel (Fig. 2, left panel).
Piezoresistive characterization studies were conducted by subjecting the self-sensing GFRP (SGFRP) specimens to cyclic loading and high sensitivity to strain was observed.
We carried out logistic regression analysis of various factors, and found that only EGFR mutations in cytology specimens represented an independent predictor for sensitivity to gefitinib.
The in-house GACELISA method detected 191/194 anti-HIV positive specimens, equivalent to a sensitivity of 99.5% (95% CI 96.7 100%).
