Additional evaluation of the new margins of cavity shaving specimens would also provide important intraoperative information.
For example, in breast cancer research, analysis of specimens from microdissection may provide important information about genes involved in different cancer development stages and for understanding the molecular mechanisms underlying cancer development [ 9].
A number of investigators have shown that laboratory testing of pleural fluid or empyema specimens in children with pneumonia can provide important insights into the origins of the pneumonia [ 51, 52].
The analysis of reliability and validity of the histopathological evaluation of core biopsy specimens of breast abnormalities is intended to provide important information needed for a high quality in breast cancer diagnostic and for planning of treatment strategies.
However, in special cases, liver histopathology may provide important diagnostic information, and the availability of liver tissue specimens or a pathology report may be useful.
More detailed investigations using banks of human tumors and clinical trial-associated specimens, to define the incidence of erbB3 abnormalities, functional complex formation and downstream signaling, may provide important new clues regarding these interactions and their role in breast carcinogenesis.
These data also provide important historical information in cases where the alien population from which a specimen was gathered is subsequently cleared.
However, negative staining has unique advantages and can provide important information on biological molecules that is not easily obtained or, in the case of very heterogeneous samples, not even possible to obtain with vitrified specimens.
Though we were not able to obtain specimens on all patients, the biomarker analyses of PBMC, archival tumor, and biopsy specimens that were obtained have provided important insights into the biology of TNBC when treated with UCN-01 in combination with irinotecan.
