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Implementation of physical phase plates into transmission electron microscopes to achieve in-focus contrast for ice-embedded biological specimens poses several technological challenges.
Thus, sampling of pathological specimens poses a challenge.
Using existing, frozen specimens poses thorny challenges in locating, confirming consent, allocating, and transporting specimens to a range of labs for a multiplicity of assays.
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Whereas modern electron microscopes can routinely deliver images of inorganic material at atomic resolution, biological specimens pose great difficulties for EM imaging, significantly reducing the attainable resolution.
The specimen poses a conundrum for researchers, because despite its impressive wings, the animal was probably incapable of flight.
A drawback of vitrification is the poor SNR in images of vitrified specimens, which poses severe difficulties especially for the study of small molecules.
Underneath were pictures of four of these enviably gorgeous specimens, provocatively posed.
Taxidermic specimens are posed in re-creations of their natural habitats, against meticulously painted backdrops showing, perhaps, the expanse of the veldt or the dense growth of a rain forest.
Degradation of specimens may pose a problem for the ensuing morphologic identification.
The concentration of Brucella organisms in the blood (11, 12) and synovial fluid (13) of patients with brucellosis is usually low, and therefore, these clinical specimens probably pose a low risk for contagion for laboratory personnel.
Some authors have suggested that intrabiliary growth at the margins of the resection specimen could pose a risk for tumor recurrence.
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CEO of Professional Science Editing for Scientists @ prosciediting.com