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Although arguably more clinically relevant, studies involving human specimens or primary cell culture present the greatest potential for uncontrolled experimental variables.
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The present study was based on a growing request to examine urine as a supplementary or primary specimen in screening for Chlamydia trachomatis in women, with the Becton Dickinson ProbeTec (BDPT) Strand Displacement Assay (SDA).
The FFPE histological tissue was accepted independent of its origin, for example surgical or biopsy specimens from primary pancreatic tumour, lymph nodes or distant metastases.
FFPE histological tissue was accepted independent of its origin, e.g. surgical or biopsy specimens from primary pancreatic tumor, lymph nodes or distant metastases.
The heterogeneity of tumors can explain the detection of these two mutations found in different subclones present in the same NB sample or in different tumor specimens (primary tumor or distant metastases) found in the same patient.
The use of archived primary tumor specimens or fresh metastatic tumor biopsies for high-throughput testing as part of a molecular screening program is an important unresolved question.
Cancer tissues collected from primary surgical specimens or mouse xenografts were immediately minced on ice, suspended in DMEM/F12 medium (HyClone, Logan, UT, USA), and dissociated with collagenase (Sigma).
Expression of the KCNMA1 gene was higher in breast tumor specimens from brain metastases compared to specimens from primary breast cancer or metastases to other organs.
Thus, novel therapies that target p53 or p185erbB-2 can utilize specimens from either primary or metastatic lesions to characterize these targets prior to therapy.
The diagnosis of MALT lymphoma was confirmed by histopathological examination of either biopsy specimens or surgically resected specimens of the primary ocular adnexal lesions.
Resection specimens of primary tumors (N = 48; primary CRCs without previous chemo-or radiotherapy) were received fresh from surgery.
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