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Further studies are required to understand the mechanism of resistance to ethambutol and to evaluate GenoType® MTBDRplus assay for the diagnosis of INH and RMP resistance from direct sputum specimens of tuberculosis patients in Ethiopia.
Although slightly lower than reported from a study using clinical specimens of tuberculosis patients in Botswana [ 7], these may be considered high enough for this test to be applied in surveys of HIV-infection among tuberculosis patients in settings with high expected HIV-prevalence.
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The sensitivity in clinical specimens of extrapulmonary tuberculosis was slightly lower, 89.5%.
During the period from January 2005 to December 2012, RGM clinical strains were isolated from the sputum specimens of suspected tuberculosis patients in Fujian, Hunan, Gansu, and Sichuan Provinces of China.
De-identified plasma samples obtained at a baseline screening visit were recruited from the specimen banks of tuberculosis case-contact studies conducted by the Medical Research Council, The Gambia, West Africa [16] and the Aga Khan University, Karachi, Pakistan [14], respectively.
Specimens for tuberculosis testing were examined by light microscopy for the presence of acid fast bacilli.
Our results show that HIV testing using the OraQuick HIV-1/2® Assay on sputum specimens of smear-positive tuberculosis patients had more than 90% sensitivity and specificity for detecting HIV-antibodies if done on the day of sputum collection.
Tasked as the expedition's naturalist, Anderson collected many bird specimens but had died of tuberculosis in 1778 before the return home.
Nucleic acid amplification assays allow for the rapid and accurate detection of Mycobacterium tuberculosis (MTB) directly in clinical specimens thereby facilitating diagnosis of tuberculosis (TB).
All patients diagnosed with active tuberculosis had positive cultures for M. tuberculosis or acid fast bacilli from one or more clinical specimens, or clinical and radiologic features highly suggestive of tuberculosis together with a good response to anti-tuberculosis treatment (table 1).
By comparison, 48% of children with active TB had culture positive specimens for M. tuberculosis of whom 19% were acid fast bacilli (AFB) smear positive (Table 2).
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