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Detailed pathology analysis of the early, non-proliferative intramucosal T1a lesions in prophylactic gastrectomy specimens of multiple family members with a c.1008G>T CDH1 germline mutation showed as the earliest, disease-initiating change reduced or absent expression of β-actin, p120 catenin, and Lin-7 compared to surrounding mucosa with general loss of organization of adherens junctions; [14].
Pathologically altered organs, entire reproductive tracts and representative specimens of multiple organs and tissues, including the brain, lung, liver, kidney, spleen, pancreas and intestine were removed at necropsy, fixed in 10% (v/v) neutral buffered formalin (NBF) overnight, transferred to 70% ethanol and paraffin-embedded.
Variance was generated by making multiple measurements across multiple angles on multiple specimens of multiple species paired against blank surfaces for four separate cues – amounting to thousands of independent measurements.
To solve this problem, some authors have suggested homogenizing the complete organ or instead obtaining and then aggregating and homogenizing random specimens of multiple parts of the placenta (Iyengar and Rapp 2001a).
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The resulting specimen of multiple spots was automatically analyzed with a time-of-flight secondary ion mass spectrometer (ToF-SIMS), and all of the secondary ions were collected.
Thus, we do not have any specific analysis of multifocality and multicentricity, but we have the notion of 'residual tumour' on the specimen in case of multiple surgery, maximal tumour size and final margin status to predict the best surgical option (especially mastectomy).
Model simulations are compared with results from experiments using cruciform specimens, of single and multiple fiber polymer-matrix composites.
None of the other types of specimens, including multiple stool or stool swab specimens on three of the patients, tested positive for SARS-CoV RNA.
Within this framework, the Cottonwood Canyon species provide a unique and critical insight into eurypterid ontogeny, with multiple instars and multiple specimens of each instar preserved in species that are phylogenetically removed from the well-studied Eurypterus.
Females were slightly more prevalent than males and an analysis of the sizes of specimens suggested the presence of multiple cohorts and continuous breeding.
Bernard Wood of George Washington University, who has studied the early Homo fossil record, wrote in a companion article in Nature, "In a nutshell, the anatomy of the specimens supports the hypothesis of multiple early Homo species".
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