In a recent study of human breast cancer specimens, activated MAPK detected by immunohistochemistry was increased in lymph node metastases compared with primary tumours, suggesting a role in the metastatic process (Adeyinka et al, 2002).
In both the examination of the cell lines in vitro as well as the tumour specimens, activated AKT was observed in the absence of HER-2/ neu overexpression.
Approximately 10% of NSCLC specimens carry activating mutations in K-ras [1].
There are two ways of activating NMDARs.
By comparing the X-ray traces of samples taken from the surface with those from the middle of the specimen shows that for activated, calcined Shahindej samples, the penetration of sulfate is very limited while for the activated, raw Shahindej, the peaks only relate to sodium aluminium sulfate.
Putatively activating NOTCH1 mutations were found in several specimens of the newly identified subgroup, while a large set of control AMLs was mutation negative.
Are our stereotypes of people activated automatically?
Uniaxial tensile tests were carried out on both un-notched and single-edge-notched tensile (SENT) specimens of two different lay-ups, (0/90 S and (45/0/−45/0)S, using a hydraulically activated load frame.
In the gastric mucosal specimens of PHG patients, GRP78, sXBP1 and p-eIF2 α were remarkably upregulated, and caspase-4 was dramatically activated compared with the uninvolved gastric mucosal specimens.
Bunker et al. found a higher prevalence of cytokines and growth factors in tissue specimens of patients with AC compared to controls, and also reported the absence of metalloproteinase MMP-14, needed to activate the proteolytic enzyme gelatinase A [7].
