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The application of qPCR to airway specimens may improve our understanding of the clinical importance of polymicrobial infection and anaerobic bacteria, progression of lung disease and ultimately improve antimicrobial treatments in CF. The authors thank Churee Pardee, Research Coordinator, and Heidi Lucky, Database Manager for assistance with this study.
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Immunohistochemical evaluation of Axl expression status in diagnostic biopsy specimens may therefore improve prognostic prediction of MPM in routine clinical practice.
Recent studies have shown that offering self-collection devices for hrHPV testing on cervico-vaginal specimens to non-attendees may improve compliance to screening [ 10- 17].
Other specimens from bone marrow and liver tissue or lymph nodes may improve recovery rates [ 3], but these specimens are invasive and are not always feasible.
Fluorescence in situ hybridization (FISH) can be used to detect chromosomal aneuploidy in biliary brushing specimens, and, according to some reports, it may improve the sensitivity of routine cytology.
On lung biopsy specimens, PCR added to histopathology and culture may improve specification of pathogens [ 58].
This approach may improve quality of the mesorectal specimens.
Thus, for specimens with AUS cytological diagnosis, additional BRAF testing may improve the sensitivity of FNA examination.
Detection of telomerase activity in preoperative specimens, such as in fine-needle aspirates (FNAs), may improve diagnostic accuracy [ 13, 14].
As the FEG improves, the induced specimen damage will be further minimized and the resolution may improve.
The study will bank biologic specimens, an increasingly common practice, so that researchers can "try again" as science advances, a strategy that may improve the payback on investments in large epidemiologic studies.
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