It is possible that mutations outside of the hotspots may contribute to loss of ACVR2 in primary colon cancer specimens, although in light of the evidence for LOH as well as epigenetic silencing, this is likely to be a less important tumorigenic mechanism.
To ensure that these networks were not an artefact of the experimental model, we assessed their expression in breast cancer specimens in the light of recently published data exploring associations between recurrent copy number abnormalities, gene expression, and clinical outcomes in a set of aggressively treated early-stage breast tumours [ 38].
In contrast, pyramidal cells in control specimens showed light immunoreactivity, with a widespread pale neuropil staining.
Both autopsy and surgical specimens showed light staining in pyramidal neurons and in endothelial cells.
Paleontologists are viewing the fossil cautiously in light of doctored specimens that have been illegally exported from China in the past, such as Archaeoraptor (Science, 22 December 2000, p. 2221).
Renewed excavation in the caves, beginning in 1958, brought new specimens to light.
In addition, like morphological data, hypotheses can be evaluated in light of additional data on specimen distribution, biology, and behavior.
The percentage of global glomerular sclerosis as a fraction of all glomeruli was determined in 39 renal biopsy specimens by light microscopy.
A margin of paler tissue representing radiofrequency ablation (RFA) thermal injury can be seen along the bottom edge of the specimen in the white light image.
The cap color is deep brown in mature specimens and lighter shades of brown in younger mushrooms.
