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In addition to efficacy and safety analyses, we report volumetric assessment of intracranial response, patterns of disease progression, correlative endpoints from archival tumor specimens, frequency of germline BRCA mutations, and quality of life among patients with TNBC-BM treated with irinotecan and iniparib.
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Method and specimen Frequency of monitoring Incidence Mortality CMV positivea CMV negativeb 1990 Domart et al. [31] Prospective, single center Mediastinitis, post-cardiac surgery Patients in whom viral cultures could be done within 10 days of surgical debridement 115 Serology for CMV IgG Viral culture blood and urine.
For each specimen, the frequency of RETs and mutant phenotype RBCs was measured by interrogating approximately 10 RBCs.
Experimental observations and analytical predictions show that the natural frequency of specimens decreased and the damping ratio of specimens increased when the braiding angle increased.
In two regions, the Lhasa region and the Nyingchi region, all studied specimens possessed indehiscent sporangia, whereas the Hengduan Mts showed a slightly higher frequency of specimens with dehiscent sporangia.
Although the causes remain to be determined, we decided to focus our attention on TSHZ2 and TSHZ3, the Teashirt family of homeobox genes that exhibited the same inclination towards a diminished expression in both established cancer cell lines and clinical specimens with the highest frequency of all candidates.
These regions are distinct in the context of the frequency of specimens with dehiscent and indehiscent sporangia and the observed genetic variation of the chloroplast genome data.
Five countries provided information on the number of specimens tested and the frequency of M. tuberculosis complex and NTM isolation (Table 4).
Consequently, we focused on the -271 G>A polymorphism in all of the specimens and analyzed the frequency of its genotypes (Fig. 1).
Among HPV infected women, independent of eventual diagnosis and the number of viral genotypes present, mid-cycle specimens yielded the highest frequency of LSIL cytologic interpretations and the highest HPV load; however, the magnitude of these effects were small.
Ovarian spermatogenesis (i.e., an ovotestis) was observed in 6 (1 normal female and 5 imposex individuals) of 92 female or imposex B. japonica specimens examined, for a frequency of about 6.5%.
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