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On the other hand, we are hopeful that the concordance in SI would remain high for lung cancer biopsies (the most common type of specimens for lung cancer diagnoses) since these are relatively small samples, and thus more similar to TMAs than full slide sections in this regard.
To compare these findings with those of viral pneumonia caused by human influenza virus, we searched archival pathologic specimens for lung tissues with histopathologic findings compatible with viral pneumonia.
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This sensitive technique could be helpful for specimens of lung cancer without removing contaminating normal cells, mostly in the setting of NSCLC, in which diagnoses are often based on bronchial biopsies or cytologic specimens.
Specimens of lung, liver and spleen were harvested and immediately fixed in 10% formaldehyde for more than 24 h.
Specimens of lung tissues were harvested.
DB contributed to the acquisition of specimens of lung tissues.
For controls, one specimen of lung tissue from a normal donor and 11 specimens of uninvolved lung tissue from patients with lung cancer were processed, ostensibly free of interstitial lung disease.
After 10d of KDITSN, the MLI showed a 48%% increase compared to controls and additional 13%% compared to the MLI values for lung specimens, 3d post-siRNAITSN delivery (Fig. 6B).
The proportion of female patients was 55 % for lung cancer specimens, 45 % for CRC specimens, and 36%% for melanoma specimens.
The age of patients ranged from 33 90 (median: 65) for lung cancer specimens, 25 90 (median: 57) for CRC specimens, and 20 94 (median: 61) for melanoma specimens.
Deceased patients for whom the family granted consent were subjected to postmortem examinations to recover lung specimens for bacteriologic culture, influenza virus detection, and histopathologic analysis.
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