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This cutoff was used to delineate specimens expressing normal levels of elafin and specimens demonstrating elafin downregulation comparatively.
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qRT-PCR experiments revealed that 6 of 7 primary lung cancer specimens expressing ≥2 fold higher miR-31 levels relative to paired normal lung tissues also exhibited over-expression of LOC554202 (Figure 4B).
All control normal specimens expressed hsp-27 by some cells in each case.
The majority of normal urothelial specimens expressed Fas, whereas in UC, Fas was downregulated.
29 showed that zero out of 20 normal lung specimens expressed pAkt and conversely that 20 out of 20 specimens expressed PTEN, which is in agreement to what is expected to find in normal lung tissue.
We found that 54.6% (24/44) of the HLA-A2-positive tumor tissue specimens expressed MAGE-A3 mRNA, which, however, was not detectable in adjacent normal tissues).
The adenoma specimens expressed greater CCK-2 receptor ΔΔCts than the adenocarcinomas (P<0.0001, Mann–Whitney), resection margin normal mucosa (P=0.0003), NIH3T3 CCK-2 receptor transfectants (P=0.005) and oxyntic mucosa (P=0.0001).
In normal or hyperplastic leukoplakia (n = 9) 7 tissue specimens were negative for K8 (78%) and 2 specimens expressed K8 weakly in 10% and to intermediate levels in 5% of the cells, respectively (Table 2).
Only 11 miRNAs (5 up- and 6 down-regulated) were found differentially expressed in normal CD34+ specimens with respect to the leukaemias.
In order to study the corresponding molecular mechanisms behind the nacre color variation patterns, a selection of genes differentially expressed between normal black specimens of pearl oyster and two types of albinos were identified using a SSH method and characterized.
To identify links between drug resistance and gene deregulation we used oligonucleotide microarray technology and determined in 184 pre-B ALL specimen genes differentially expressed compared to normal CD34+ specimens.
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