In this study, we showed that human HCC specimens expressed the MK gene more frequently than the AFP gene and that the transcriptional activity of the MK promoter was as strong as that of the enhancer-linked AFP promoter.
Three HCC specimens expressed the AFP gene and one of the AFP-positive samples was also AFP-positive in the corresponding noncancerous region (Table 1> -wrap-foot>, Figure 1 ).
Moreover NHL specimens expressed the adiponectin receptors, suggesting that adiponectin may represent not only a potential clinically significant diagnostic and prognostic marker but also a molecule that may be implicated in NHL pathogenesis [ 60].
When analysing the pattern of IxAC expression in 10 individual adult females we found that no single specimen expressed the whole range of anticomplement IxAC proteins.
Sixty percentage (48/80) of specimens were CD133-positive, with less than 15% cells per specimen expressing the marker.
Our group has recently confirmed that almost the 70% of MM cells in BM specimens express CD200 and, as in melanoma, the dependence of CD200 expression on RAS/RAF/MEK/ERK pathway.
More importantly, the majority of tested primary OS specimens express EPHA2, indicating that when applying targeted drug delivery towards this receptor, a majority of patients may benefit.
The invasive breast cancer cell lines and clinical specimens express high levels of Runx2 compared to non-tumorigenic breast epithelial MCF-10A cells (Additional file 1: Figures S1A, S1B, Additional file 2: Figure S2 and [ 5, 6, 15]).
Since glioblastoma cell lines and tumour specimens express both canonical and non-canonical Wnt, it is tempting to speculate the modulation of Evi might disturb a finely tuned balance between canonical and non-canonical signalling required for homoestasis.
To investigate whether breast cancer cells freshly derived from clinical specimens express heterogeneous stem cell markers as observed in human breast cancer cell lines, we performed stem cell marker profiling by FACS analysis of nineteen specimens obtained from National Taiwan University Hospital.
