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The invasive breast cancer cell lines and clinical specimens express high levels of Runx2 compared to non-tumorigenic breast epithelial MCF-10A cells (Additional file 1: Figures S1A, S1B, Additional file 2: Figure S2 and [ 5, 6, 15]).
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Additional file 1: KRAS mutant NSCLC specimens express higher p-PAK1 compared to KRAS wild type specimens.
Finally, we identified vascular channels in necrotic areas of primary human high-grade invasive breast cancer specimens that express high levels of COX-2, suggesting that these channels may serve as an alternative means of generating microcirculation in hypoxic regions of the tumor and thus facilitate metastasis.
Human high-grade invasive tumor specimens that expressed high levels of COX-2 proteins had detectable vascular channels, whereas low-grade tumors with no or low COX-2 expression had little evidence of VM.
Osteoblasts express high levels of TNFR-1.
Significantly more specimens expressed a high malignancy grade when the tumour had become hormone resistant than at the time of initial diagnosis (Gleason P: < 0.0001, WHO P 0.0003).
Fibroblasts in inflamed or healing tissues express higher levels of SCF, and upregulation of SCF expression has been noted in synovial specimens exposed to TNF [ 99- 101].
Conversely, metastatic prostate specimens express CAR (Rauen et al, 2002).
The NF-κB activities of SCCHN cell lines with different metastatic potentials were then determined and in excellent agreement with results found in SCCHN specimens, highly metastatic SCCHN cell lines expressed high level of NF-κB activity.
qRT-PCR experiments revealed that 6 of 7 primary lung cancer specimens expressing ≥2 fold higher miR-31 levels relative to paired normal lung tissues also exhibited over-expression of LOC554202 (Figure 4B).
In fact, as found in melanoma specimens (Schadendorf et al, 1995b; Moral et al, 1997), A375 cells expressed high levels of GSTP1 and MRP1, whereas very lower levels of GSTM1 and MRP3 were detected.
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