Sentence examples for specimens and validation from inspiring English sources

The method, manufacturing of test specimens, and validation are presented.

This will provide the potential for discovery using FFT specimens and validation with FFPE specimens.

Therefore, it is essential to assess drug or target delivery into primary tumors and yet the identification of reovirus in primary tumor specimens and validation of biomarkers of clinical activity have not been investigated in pancreatic cancer.

A major limitation to further development for clinical use might have been that these studies analyzed small numbers of breast cancers and matched control specimens, and validations with larger patient cohorts were not pursued [ 13- 15].

In the aggregate cohort of 22 specimens (discovery and validation cohorts), the presence of H3F3A K27M in Grade III and IV (85.7 %, n = 6/7 specimens) and absence in Grade I and II (n = 0/15 specimens) astrocytomas was a statistically significant difference (p < 0.001, Chi squared test with Yates correction).

The process requires multiple steps, including lock-down of the assay and classifier, then internal validation on suitable specimens, and then external validation on independent set(s) of specimens/data.

Even when all of the above limitations are met there has been a considerable shortage of quality specimens for discovery and validation studies that overcome the biases inherent in retrospective samples [ 5].

Methods: Three different hospitals participated in a patient specimen and analytical validation study (n=186) for the i-STAT cTnI assay carried out in real time.

Real-time PCR techniques are now commonly used for the detection of viral genomes in various human specimens and require for validation both external and internal controls (ECs and ICs).

ccRCCs are hypervascular tumors with an increased opportunity for infiltration of non-cancerous cells such as lymphocytes [ 21]: the microscopically examined tumor cell contents of all ccRCC tissue specimens in the learning and validation cohorts are shown in Additional file 3: Table S3.

In addition to designing an assay, collecting specimens for validation, and completing the validation, they must also design and implement a quality system to ensure continued performance of the assay.