Moreover, the involvement of rare earths further decreases the average friction coefficient and the wear rate of specimens, and improves the corrosion resistance.
The greatest improvements in overall performance of the laboratory testing cycle will be achieved through increasing the speed of specimen transport and improving transmission of clinical data to and from the laboratory.
The kaolin paste allows more time to set up the specimen and improves the contact condition between the residual soil specimen and the HCT.
It has long been known that applying a negative potential to the sample reduces beam-landing energies and, thereby, reduces beam damage to the specimen and improves surface detail.
These applications could result in a decreased time to diagnosis, reduced rate of re-excision, lower cost of pathology specimen processing, and improved patient care.
Assessment of mutational load using our panel of LOH mutational markers may be a useful adjunct to microscopic inspection of biopsy specimens, and thereby, improve patient management.
To circumvent some of the difficulties presented by the structural heterogeneity of our specimens and to improve the resolvability of features, we extracted subtomograms from the fibril-bound and freestanding TRiC populations and processed them separately to obtain 3-D averages.
Electron microscopes with helium-cooled top-entry specimen stages, such as the one developed by Fujiyoshi and co-workers (55), and improved specimen preparation methods, such as the carbon sandwich technique (56), have especially helped to improve the yield of high-resolution images.
The quality of X-ray spectra from FEGTEMs has been improved by three different means: the use of beryllium shields, improved collimation and improved specimen holder geometry.
Further application of direct detectors for data collection, combining with other image-processing algorithms, and improved specimen-preparation methods should bring other advances in the use of cryo-EM for structural virology.
