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The transparency of the specimens allows us to directly observe the propagation of the purely planar crack obtained during a DCB (double cantilever beam) test.
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The ability to use archival dysplasia specimens allowed us to relate the findings of DNA content analysis to long-term clinical outcome regarding progression to carcinoma.
Although TURP is not the standard modality for the diagnosis of prostate cancer, the use of TAPG TURP specimens allowed us to assemble a unique cohort of untreated men with prostate cancer with up to 20 years of follow-up and thereby study the association of DNA methylation to death from prostate cancer.
Testing of stored baseline specimens allowed us to pinpoint seroconversion and rule out acute prestudy infections.
Genetic analyses of DNA extracted from museum specimens allowed us to directly assess the patterns of genetic variation and structure in the historical Finnish wolf population.
The high isotropic resolution in this study and the relatively thick cartilage of the lateral femoral condyle specimens allowed us to perform a zonal T2*and T1Gd assessment within articular cartilage in order to recognise variations in the zonal anatomy of articular cartilage in various stages of cartilage degeneration.
The use of a single, rescannable (over long time) specimen allows us to build a spatially consistent model, easily expandable with new scans, benefiting this way of fast developments in diagnostic imaging.
Molecular testing of the surgical specimen allowed us to identify E. granulosus DNA, genotype G1, in the nucleated inner layer of the cyst wall.
The damaged specimens also allow us to determine the influence of a local reduction of the cross section on the stiffness and ultimate load of the specimen.
We further acknowledge the PRE, NU, GRA, BOL and PRU herbaria for providing herbarium specimens and allowing us to take material for DNA extraction.
Related trials including aromatase inhibition with or without gefitinib have not yet demonstrated clear clinical advantages, but they have provided tumour specimens that allow us to try to elucidate where and how such combinations might be effective [ 10, 11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com