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The fifth specimen with poor TIL growth (M40) proved to be highly necrotic upon microscopic examination (data not shown).
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In a biomechanical study on cadaver spine, using BAK cages and translaminar screw, Rathonyi et al [ 17] observed very poor rotational stability in specimens with poor endplate contact.
Likewise, specimens with poor bone density are recommended to be exposed to different in vitro loads than those that do not have any sign of bone degeneration [ 21].
The absence of centromere signal was used to exclude regions of tissue or slides (three specimens) with poor fixation and inadequate PNA hybridization.
The present study showed that high p21 expression level in the pre-CRT specimen was associated with poor pathologic regression and worse DFS after CRT.
Clinically, resected PC specimens with a poor histopathologic response to neoadjuvant therapy represent a group of treatment-resistant tumors.
Low transcript levels for Stat5a but not Stat5b in breast cancer specimens were associated with poor clinical outcome.
In the current study, we demonstrate that down-regulation of S100A16 expression in OSCC specimens was associated with poor prognosis and poor differentiation grade.
The combination of high CysLT1R expression and low CysLT2R expression in colon cancer specimens is correlated with poor survival prognosis and disease outcome [ 18, 20].
Recent work has demonstrated that cytoplasmic c-Src and fully activated membrane Src phosphotyrosine 419 expression in breast cancer specimens was associated with poor clinical outcome (Elsberger et al, 2009).
COX-2 overexpression in tumour tissue was found in 103 of 212 (48.6%) tumour specimens and correlated with poor disease-free (P=0.02, Figure 2A ) and overall survival (P=0.04, Figure 2B).
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