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In these 15 representing clinical specimen, the expression pattern of ADAM17 was similar by the monoclonal antibody and the polyclonal antibody when compared in sequential slides (Supplementary Figure 5a f).
For each specimen, the expression level of each gene superfamily is the sum of expression levels (TMM-normalized FPKM) of the conopeptides belonging to that superfamily represented as "sum TMM-normalized FPKM".
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As miR-204 is specifically downregulated in GC specimens the expression of its putative targets might be upregulated.
In DCIS tumour specimens the expression of HER4 was associated with positive ER status and a low proliferation rate, suggesting HER4 as a favourable prognostic marker.
In non-neoplastic breast specimens the expression levels of all detected VEGF-A-isoforms (189, 165, 121) were significantly higher in premenopausal compared to post-menopausal women (P = 0.02) and were inversely correlated with the patient's age (P = 0.006).
Indeed, in the young specimens the expression pattern of all tested molecules appears concentrated at the gut level, whereas in adult the gut loses its key role that is mostly supported by skin.
In the same specimens the expression of fibronectin integrin receptors was evaluated.
In CSCs isolated from primary PDAC surgical specimens, the expression of CD95 positively correlates with EMT markers.
In comparison with nonmetastatic specimens, the expression of CLCA1 was downregulated significantly in metastatic CRC (P <.01; Fig. 4B).
Of the 57 OSCC specimens, the expression of NANOG was strong in 21 specimens, moderate in 18 specimens, and weak or negative in 18 specimens.
In a different cohort of 122 human breast tumors and 32 normal breast specimens, the expression of CCN3 was found to be lower in tumor tissues when compared to normal specimens [ 79].
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