Detailed pathology analysis of the early, non-proliferative intramucosal T1a lesions in prophylactic gastrectomy specimens of multiple family members with a c.1008G>T CDH1 germline mutation showed as the earliest, disease-initiating change reduced or absent expression of β-actin, p120 catenin, and Lin-7 compared to surrounding mucosa with general loss of organization of adherens junctions; [14].
Pathologically altered organs, entire reproductive tracts and representative specimens of multiple organs and tissues, including the brain, lung, liver, kidney, spleen, pancreas and intestine were removed at necropsy, fixed in 10% (v/v) neutral buffered formalin (NBF) overnight, transferred to 70% ethanol and paraffin-embedded.
Variance was generated by making multiple measurements across multiple angles on multiple specimens of multiple species paired against blank surfaces for four separate cues – amounting to thousands of independent measurements.
To solve this problem, some authors have suggested homogenizing the complete organ or instead obtaining and then aggregating and homogenizing random specimens of multiple parts of the placenta (Iyengar and Rapp 2001a).
Thus, we do not have any specific analysis of multifocality and multicentricity, but we have the notion of 'residual tumour' on the specimen in case of multiple surgery, maximal tumour size and final margin status to predict the best surgical option (especially mastectomy).
The test data also demonstrated that a single fatigue test at GIIimax = 0.3GIIc, would be sufficient to generate the complete da/dN growth rate data instead of multiple specimen tests at different values of GIIimax.
Streptococcus pneumoniae rDNA sequence microheterogeneity was found in one pleural fluid specimen, suggesting the presence of multiple strains.
In this study, we examined the diagnostic yield of multiple specimen types for pediatric TB in a rural, resource-limited operational setting.
Histologic examination of the biopsied specimen revealed the presence of multiple vacuolated cyst-like areas, surrounded by a granulomatous foreign body reaction composed predominantly of histiocytes, foamy macrophages and lymphocytes.
Also, as this is the first instance of multiple specimen source-specific interpretive breakpoints for a single organism-antimicrobial agent combination, education of laboratory staff and clinicians was required, likely further complicating the implementation of the new criteria.
