In the center of the minute specimen of brain cells was a pink circle, known as a kuru plaque, one sign of a strange family of diseases known as slow viruses.
Women were asked to provide a specimen of buccal cells using a collection protocol previously outlined by Richards and colleagues [ 62].
Interestingly, in the case of stromal cells derived from a surgical tissue specimen of squamous cell cancer of oesophagus, the cyclin D1 expression in tumour stromal cells was downregulated as compared with that observed in normal stromal cells.
We have now identified a somatic non‐synonymous mutation of mTOR that results in a leucine‐to‐valine substitution at amino acid position 2209 in a specimen of large cell neuroendocrine carcinoma.
We have now identified somatic single nucleotide variations in a specimen of large cell neuroendocrine carcinoma (LCNEC), one of which results in a Leu‐to‐Val substitution in mTOR.
Currently available cell lines likely reflect certain biases in the specimen source of cell line, and/or in the culturing methods, as suggested by the predominance of HCC lines (from UT Southwestern) among the basal-A group.
In an exemplary proof of concept application, we used dimethyl labeling to profile proteome changes in FFPE tissue specimens of clear cell renal cell carcinoma (ccRCC), comparing ccRCC to adjacent non malignant renal cells.
As a clinical application, four FFPE tissue specimens of clear cell renal cell carcinoma (ccRCC) and adjacent non-malignant kidney tissue were chosen.
For each specimen, the percentage of cells with apoptosis and NO was plotted against time from injury and correlation coefficients were calculated (SPSS 15.0 for Windows; IBM, Somers, NY, USA).
Specimens of meniscal cells in this 3D construct were easily fed, handled and processed for histologic examination.
