In 1947, H J Sawin proposed that the aetosaur Longosuchus was a scavenger based on the close proximity of some specimens to a large number of skeletons that were likely carcasses.
In toto imaging of fluorescent protein expressing specimens on a large-scale could be used for generating high-resolution digitally recorded anatomical databases where the baseline (wild-type) cell behaviors and cell fates can be contrasted to those observed in mouse mutants.
A control group of 90 patients consisted of patients who consulted the colposcopy clinic at the UMC between 1997 and 1999 and who were diagnosed with high-grade CIN in the biopsy specimen of a large-loop excision of the transformation zone.
Naturally this prevents the use of specimens of a large number species that are now either extinct, or that have not been collected recently and preserved specifically for molecular work.
To identify which patients might benefit from focal ablative techniques, we analysed the surgical specimens of a large sample of population-detected men undergoing radical prostatectomy as part of a randomised clinical trial.
Data from an RCT and availability of specimens from a large number of patients are both essential for a sound retrospective validation, as otherwise it is impossible to isolate any causal effect of the marker on therapeutic efficacy from the multitude of other factors arising from a non-randomized design and/or selected samples [ 24, 25].
The surface profile of a specimen with a large height step is measured to prove the feasibility of the proposed method.
Due to the fact that the specimens should not be destroyed by the one and only impact, a compact design of a specimen with a large bonding area using two symmetrically positioned adhesive layers was considered to be of more practical use in the Charpy machine.
The low rate of morphological specimen identification says little about the ability of taxonomists to identify a specimen in hand, but much about the difficulty of placing every specimen from a large survey into the hands of the appropriate specialist [ 23, 34].
Two studies have recently described the comprehensive analysis of whole-genome methylation patterns of HPV16, HPV31, HPV18, and HPV45 in a greater number of specimens from a large cohort study [ 68, 69].
The assay, however, needs to be verified using a large number of clinical specimens from a large number of patients, with reference to the current diagnostic standard, before it is acceptable to introduce this new test to routine care.
