The polarizing region, a small group of cells at the posterior margin of the limb bud, acts as a signalling region to specify the pattern of structures which develop across the anteroposterior axis of the limb1.
These proteins generally are expressed in a localized manner, and they may elicit distinct concentration-dependent responses in the cells of surrounding tissues and structures, thus functioning as morphogens that specify the pattern of cellular responses by their tissue distribution.
These genes act early during oogenesis to establish the spatial pattern of the egg chamber as a whole, including both the pattern of the egg shell which is produced by the follicle cells situated on the outside of the egg chamber as well as the spatial distribution, or local activation of the maternal cytoplasmic determinants that specify the pattern of the embryo.
This approach is implemented in Robo-Sensei: the system asks the student to answer a specific question, and then compares the response with an "answer schema" that specifies the pattern of the expected correct response.
Nucleus-encoded proteins destined for different subcellular locations have measurable distinct phylogenetic distributions of homologs that can be described with a phylogenetic profile that specifies the pattern of occurrence of a given protein among completed sequenced organisms.
Systems of this kind allow the user to specify the pattern of interest and can enhance the analytic process with advanced interfaces [ 22, 23].
We show that cells both generate and respond to epithelial stresses during this process, and that the nature of this interplay specifies the pattern of junctional network remodeling that changes wing shape.
The HOX family of genes specifies the patterning of body segments along the anterior posterior axis by encoding homeodomain transcription factors essential for embryonic development (4, 20).
But he is specifying the pattern: that births of endemic, congeneric species follow soon after the deaths of predecessor species.
In brief, the binary code strategy posits that stably folded proteins can be encoded by specifying the sequence pattern of polar and nonpolar residues (the binary pattern) to coincide with the exposed and buried parts of a structure, respectively.
