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Specifically, the 2 contrasts were: " repeat action-selection" versus " repeat specified trials" and " non-repeat action-selection" versus " non-repeat specified trials".
There were 2 types of specified trials: repeat and non-repeat.
This model also included 4 regressors for each of 2 first-level contrasts, " repeat action-selection" versus " repeat specified trials" and " non-repeat action-selection" versus " non-repeat specified trials", and regressors for the measure of disease severity (UPDRS).
Fifty percent of the specified trials were a repeat response of the previous trials, 50% of the action-selection trials had an option to repeat the response and 50% of all trials enforced a switch to an alternate response.
fMRI demonstrated that for all subjects all action-selection trials, compared with all specified trials, activated a frontoparietal network, including bilateral superior parietal cortex, left dorsal premotor cortex, left ventral premotor cortex and left middle frontal cortex (Table 2, Fig. 3 A).
The contrast between selection and specified trials we have examined could include several cognitive processes including conflict detection (Kerns et al. 2004; Ridderinkhof et al. 2004), set-switching (Brass and von Cramon 2002; Rushworth et al. 2002, 2003), and selection of responses by provision of top-down bias between competitive effectors (Rowe et al. 2005).
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Patients, aged 18 60 years, scheduled for a routine dental check-up were sent an information leaflet about the trial and allocated an appointment during a specified trial recruitment session.
The model provides facilities for selecting a cohort of simulated subjects meeting trial inclusion/exclusion criteria and then simulating each subject's life for the duration of the trial according to the specified trial protocol.
If your spouse is against homeschooling, ask him or her to agree to a specified trial period, after which you will place your child in school if homeschooling does not work out.
For the above reasons even if the probabilities under the alternative hypothesis are correctly specified, some trials of high-risk subjects may be more expensive than larger trials of average-risk subjects with the same power and type I error.
The objective of this study was to evaluate the adequacy of reporting of randomised trials on diseases of the digestive system registered in http://ClinicalTrials.gov and to evaluate the consistency between primary outcomes, secondary outcomes and sample size specified in trial protocols and published trials.
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